• Valinomycin Having established the critical necessity of UBE

  2020-07-31

  

  Having established the critical necessity of UBE2J2 for degradation of SQLE, we considered the possibility that its expression may be sensitive to the cellular sterol-status, as this may allow coupling of its activity to metabolic demand. However, while expression of the SREBP targets HMGCR and SQLE

• cyclin dependent kinases The RING finger and the U box type

  2020-07-31

  

  The RING-finger and the U-box- type E3 ligases act as a scaffold protein to bridge an E2 enzyme and a substrate proximally for ubiquitin conjugation (Fig. 1). The RING-finger-type E3 ligases are generally thought to be the biggest family of ligases and contain a Zn2+-coordinating domain with spaced

• br Introduction DNA damage repair is essential life processe

  2020-07-31

  

  Introduction DNA damage repair is essential life processes for maintaining the integrity and stability of genomic DNA, in which many enzymes, bio-molecules and ribozymes participate (Friedberg, 2003, Sancar et al., 2004, McCabe et al., 2006). In particular, the ligation reaction of 5′-phosphate a

• br DNA alkylation Alkylating agents damage DNA by introducin

  2020-07-31

  

  DNA alkylation Alkylating agents damage DNA by introducing a methyl/ethyl group on available nitrogen and oxygen atoms in its bases. These chemicals can be divided into two subgroups, SN1 and SN2, according to their reaction mechanisms. The SN1 type, e.g., N-methyl-N-nitrosourea (MNU) and N-methy

• Sequence alignment of cfALDH with the human ALDH indicates

  2020-07-30

  

  Sequence alignment of cfALDH with the human ALDH1 indicates that the cyanobacterial protein contains the same GQCC motif as the human ALDH1 and ALDH2 proteins [24] (Fig. 1d, highlighted in red, and Supplementary Fig. 2). This motif is present in ALDH1/2 orthologues and these residues reside at the b

• Some V PPase genes of plants are inducible and

  2020-07-30

  

  Some V-PPase genes of plants are inducible and have essential roles in plant development and response to environmental changes [4], [36]. Stress conditions, such as cold, anoxia, chemical stimulation, wound, salt, osmotic shock and plant hormones, etc., could induce the gene lomitapide and enhance t

• The NMT data showed greater Na efflux and H

  2020-07-30

  

  The NMT data showed greater Na+ efflux and H+ influx in the roots of transgenic plants compared with the WT after salt stress (Fig. 12), which indicated stronger activity of the Na+/H+ antiporter salt overly sensitive 1(SOS1) in the transgenic Arabidopsis (Jian, 2009, Sun et al., 2009). The possible

• In addition we examined the influence of chronic restraint

  2020-07-30

  

  In addition, we examined the influence of chronic restraint stress on the alteration of CYP3A activity in the liver of mice with a selective ablation of the GR in the noradrenergic system (Figs. 1A and 1B). Indeed, stress is a fight-or-flight response to stressful stimuli that helps an individual to

• This lack of modeling to minimize toxicity

  2020-07-30

  

  This lack of modeling to minimize toxicity is surprising in some ways, because CPA toxicity has been highlighted as one of the chief impediments to successful cryopreservation of tissues and organs [28]. This, coupled with the fact that great gains have been made in the area of single cell suspensio

• In recent years ChEs activity

  2020-07-30

  

  In recent years, ChEs activity has been increasingly used in environmental bioengineering to detect exposure to ChEs inhibitors such as OPs. The ChEs activities of whole blood, red blood cells and plasma were detected in this study. ChEs activity in exposure group was lower than that of in control

• Here we examine the effects

  2020-07-30

  

  Here, we examine the effects of MBNL1-3 and CELF1-6 on DM. CLCN1 is thought to be responsible for myotonia, the most characteristic symptom in DM1 [17]. Many studies have been performed using mouse Clcn1. In these models, a frameshift occurs following the insertion of exon 7A (79 bp) between exon 6

• In general cellular senescence is

  2020-07-29

  

  In general, cellular senescence is considered a programmed response to stress that can be activated by oxidative stress, irradiation or action of substances or drugs. These stressors cause DNA damage and, through the action of specific proteins (p53 and p21), lead to cell senescence (di Fagagna, 200

• Adaptation to psychological or physiological stressful

  2020-07-29

  

  Adaptation to psychological or physiological stressful circumstances requires integration of behavioral, neuroendocrine, and autonomic responses to maintain homeostasis. The LC is regarded as a part of the central ‘stress circuitry’, which is robustly activated after stressful stimuli in experimenta

• DNA PK is a heterotrimeric complex consisting of

  2020-07-29

  

  DNA-PK is a heterotrimeric complex consisting of the catalytic subunit DNA-PKcs and a heterodimer of Ku70 and Ku80. DNA-PK binds dsDNA breaks and functions in non-homologous end joining (NHEJ) (Pannunzio et al., 2018) and also in DNA sensing, upregulating type I IFN and cytokines via the STING pathw

• br Introduction br Sphingolipid metabolism

  2020-07-29

  

  Introduction Sphingolipid metabolism Sphingolipids, are fundamental constituents of all eukaryotic membranes and their metabolism is carried out by a broad array of anabolic and Puromycin with ceramide as their hub (for a review, (Hannun and Obeid, 2018)). Ceramide can be formed by multiple p

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