• Our results show that COX and COX inhibition

  2020-01-06

  

  Our results show that COX-1 and COX-2 inhibition improve cognitive performance and decrease the neuronal insult during HH. However, when a neuroinflammatory response was observed, COX-1 inhibition was more effective than COX-2 inhibition at reducing microglial activation and augmenting pro-inflammat

• EphB and ephrinB mRNA levels were determined from

  2020-01-06

  

  EphB4 and ephrinB2 mRNA levels were determined from three parts taken from each tumor, and each sample was analyzed in triplicate. The differences in the histoscores and mRNA levels of EphB4 and ephrinB2 were analyzed by Student\'s t test. The correlation coefficients were evaluated both by linear r

• Two photon microscopy experiments demonstrated that most con

  2020-01-06

  

  Two-photon microscopy experiments demonstrated that most contacts between GC B and Tfh cells are of short duration (about 2 min), and only about 4% of these contacts lead to the formation of stable conjugates (5 to 60 min) (Allen et al., 2007). Similarly, during extrinsic peptide stimulation, some r

• In the absence of ligand

  2020-01-06

  

  In the absence of ligand RNA, 2CARD of RIG-I is masked by the intramolecular interaction with the helicase domain, showing auto-repressed state [33], [34]. But upon viral RNA binding, 2CARD of RIG-I is exposed to interact with the CARD domain of MAVS (also known as Cardif, IPS-1 or VISA) on mitochon

• OTX-015 receptor Introduction Cognitive impairment is a core

  2020-01-06

  

  Introduction Cognitive impairment is a core, stable feature of schizophrenia that limits patient functioning and well-being (Keefe and Harvey, 2012) and associates with poor functional outcome (Fervaha et al., 2014, Kontaxaki et al., 2014). Studies also indicate that cognitive deficits occur prior

• br Author Contributions br Acknowledgments This

  2020-01-06

  

  Author Contributions Acknowledgments This work was supported, in part, by a grant from the National Cancer Institute of the National Institutes of Health under Grant U01CA202241 and National Institutes of Health under Grant R01NS083856. Introduction The Eph (erythropoietin-producing human

• br Disclosure statement br Acknowledgment This

  2020-01-06

  

  Disclosure statement Acknowledgment This work was supported by the National Natural Science Foundation of China (81270704, 81330018). Background Over-expression of cyclooxygenase-2 (COX-2) is common in many malignancies including non-small cell lung cancer (NSCLC) and is associated with po

• According to the Nomenclature Committee of the International

  2020-01-06

  

  According to the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB, 1992), peptidases are divided into two classes, namely exopeptidases and endopeptidases, based on their actions on substrates and their active sites, respectively. Endopeptidases inclu

• Recently experimentally exposed common carp took up CLO

  2020-01-03

  

  Recently, experimentally-exposed common carp took up CLO from water and maintained a consistent concentration in the liver and blood plasma (Corcoran et al., 2014). Clotrimazole may influence other aquatic organisms. Survival and development of marine shrimp larvae (Palaemon serratus) were affected

• 3-Deazaadenosine br Material and methods br Results br Discu

  2020-01-03

  

  Material and methods Results Discussion Isolated 3-Deazaadenosine have several potential advantages over other in-vitro approaches, such as expression of properties similar to their site of origin including the possibility of bidirectional transmembrane transport and exposure. Furthermore,

• In a study performed simultaneously

  2020-01-03

  

  In a study performed simultaneously by another group, EWS-FLI-1 introduction into unsorted murine bone marrow-derived N-3-oxo-dodecanoyl-L-Homoserine lactone resulted in tumors with various phenotypes including one that is consistent with that of Ewing sarcoma [68]. The tumors expressed markers ass

• Protein ubiquitination occurs at the lysine residues and is

  2020-01-03

  

  Protein ubiquitination occurs at the lysine residues, and is mediated by the sequential reactions of ubiquitin-activating enzyme (E1), conjugating enzyme (E2), and ligase (E3). The first step in this process comprises the ATP-dependent activation of ubiquitin by E1 to form a ubiquitin–E1 conjugate.

• br Conclusions br ISG is an ubiquitin like protein that

  2020-01-03

  

  Conclusions ISG15 is an ubiquitin‐like protein that is induced by treating mammalian Caspase-3, human recombinant proteinase with interferon‐α/β. UbE1L was identified as the E1‐activating enzyme for ISG15 in the course of experiments that demonstrated that the nonstructural or NS1 protein of in

• br Conflict of interest br Acknowledgements The authors are

  2020-01-03

  

  Conflict of interest Acknowledgements The authors are grateful to laboratory technician Kristina Andersson for expert technical assistance. The authors acknowledge the Swedish Research Council (Grant no. 6834), Region Skåne and Faculty of Medicine, Lund University, for financial support. In

• We initially identified four putative

  2020-01-03

  

  We initially identified four putative Egr1 Flubendazole (−39/−36, −105/−102, −107/−104, and −227/−224) on the DBH proximal promoter. The deletion and mutagenesis experiments indicate that the motif at −227/−224 is required for Egr1-elicited reduction in DBH promoter activity. It remains to be deter

15953 records 898/1064 page Previous Next First page 上5页 896897898899900 下5页 Last page