• br Epigenetic regulation of genes involved in

  2019-05-27

  

  Epigenetic regulation of genes involved in hepatic lipid metabolism by S1P and SHP The signaling cascade of CBA > S1PR2 > SphK2 > S1P > HDAC1/2 > increased hepatic gene expression can differentially up-regulate blocks of genes involved in the hepatic metabolism of sterols and lipids (Fig. 3, Tabl

• En el segundo grupo se ubican los pueblos

  2019-05-27

  

  En el segundo grupo se ubican los pueblos indígenas y comunidades afectadas por la industria extractiva, los mismos que han protagonizado intensas y masivas protestas en puntos tan disímiles del territorio nacional como Cajamarca, Arequipa, Piura o la Amazonía. Se trata de diversas poblaciones que o

• La Proclama se alaba que

  2019-05-27

  

  La “Proclama” señalaba que las Fuerzas armadas asumían la conducción del Estado con el propósito de “terminar con el desgobierno, la corrupción y el flagelo subversivo.” En Guatemala, el “Comunicado Urgente al Pueblo” inmediatamente después del golpe del 23 de marzo de 1982 decía que: “El ejército

• order niclosamide Ad Mapu lleg a convertirse en un gran refe

  2019-05-27

  

  Ad Mapu llegó order niclosamide convertirse en un gran referente que contribuyó al fortalecimiento de la conciencia de la situación mapuche, así lo explica Víctor Toledo al mencionar que es en este momento cuando aparece bosquejada la autodeterminación como propuesta del pueblo mapuche, y recuerda l

• br Prognosis The management of AML in the elderly patient

  2019-05-27

  

  Prognosis The management of AML in the elderly patient presents a significant challenge for hematologists. Careful evaluation of both patient and disease is required in each individual case to make optimal management decisions, and maximize the benefit to the patient. Apart from the extremely old

• Acute kidney injury is a common

  2019-05-27

  

  Acute kidney injury is a common disorder worldwide, occurring in more than 13 million people every year, 85% of whom live in low-income or middle-income countries (LMICs). The disease imposes a severe burden of morbidity and mortality, with a major economic effect on health-care expenditure worldwid

• keap1-nrf2 pathway The study reported high rates

  2019-05-27

  

  The study reported high rates of antimicrobial resistance and also reminds us of the paucity of new drugs to treat such infections, especially in neonates, as well as the paucity of data on antimicrobial pharmacokinetics in this population. Observational and interventional multicentre studies are n

• Era tal el recelo que hab a

  2019-05-24

  

  Era tal el recelo que había sobre el enriquecimiento de los ministros que en enero de 1622 se intentó investigar los orígenes de su riqueza. El mismo mes se publicó un decreto que estipulaba que todos los que habían tenido cargos prostaglandin receptor partir de 1592 debían inventariar sus propiedad

• In addition we are continuing

  2019-05-24

  

  In addition, we are continuing our regular editorial policies of commissioning more specialised Clinical Reviews and Series across Group to provide a more focused and in-depth assessment for key diseases. And beyond providing knowledge and information, we want to encourage academic and practising cl

• Declaration of interests br Abstract

  2019-05-24

  

  Declaration of interests Abstract Background In times of seawater inundation in coastal deltas, unprotected drinking water sources, such as ponds and shallow tube wells, take on salt water with each inundation. Daily consumption of these saline sources contributes to overall sodium intake. Altho

• nmda receptor The care or intervention provided during the E

  2019-05-24

  

  The care or intervention provided during the ED stay for critically ill patients significantly impacts the progression of hospital outcomes. Svenson and colleagues reported that nmda receptor critically ill patients received critical care procedures commonly performed in the ED while waiting for IC

• br Conclusion br Conflict of interest br

  2019-05-24

  

  Conclusion Conflict of interest Introduction Classically, cancer has been described as a disease involving uncontrolled cell growth. Now, however, it is apparent that cancer growth and metastasis are not solely dependent on the tumor SRT 1720 themselves, but involve pathologies in the surr

• glucokinase The width of the QRS is

  2019-05-24

  

  The width of the QRS is often used to ascertain the distance of the site of origin from the conduction system. In the absence of antiarrhythmics, which result in conduction slowing, VTs with narrow QRS are located closer to the purkinje system or septum. VTs originating from the epicardium have been

• csf1r In focal coronary spastic angina

  2019-05-24

  

  In focal coronary spastic angina, intravascular ultrasound was reported to detect intima–media complex thickening and an increased sonolucent zone [16,17], and OCT can detect intimal thickening with low lipid and calcium deposits [18], which are believed to reflect neointimal hyperplasia subsequent

• The answer is D This patient had a

  2019-05-24

  

  The answer is D. This patient had a typical Brugada type 1 ECG pattern. Coved ST-segment elevation of more than or equal to 2mm in at least either lead V1 or V2 with T-wave Rapalink-1 is considered typical type 1 pattern; this was not STEMI, and hence, option 1 is incorrect. As per the 2015 Europea

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