This study indicates that miR and miR may also be

2018-10-20

This study indicates that miR-124 and miR-219 may also be involved in the neurogenesis-to-gliogenesis switch by NSPCs. miR-124 promotes neurogenesis via downregulation of several genes (Sox9, Scp1, and Ezh2) that are positive regulators of gliogenesis or negative regulators of neurogenesis in the de

Our initial endeavors in characterizing our isogenic

2018-10-20

Our initial endeavors in characterizing our isogenic iPSCs lines included a microarray-based large-scale gene Apremilast analysis comparing the HD iPSCs with the corrected line C116 iPSCs (An et al., 2012). These studies were restricted to a comparison of only the iPSCs lines but yielded several use

To elucidate whether the expression pattern

2018-10-20

To elucidate whether the expression pattern of Zscan4 has any correlation with ESC proliferation, we monitored Zscan4 activity at single cell level. Also to see whether the rejuvenation factor Zscan4 correlates with the fluctuating wave of ESC pluripotency (Figure S1), we monitored Zscan4 and the pl

We have developed protocols to

2018-10-20

We have developed protocols to form 3D force-generating engineered heart tissues (EHTs; Eschenhagen et al., 2012; Hirt et al., 2014). This follows the principle of hydrogel formation with dissociated cardiomyocytes in casting molds and maintenance with a defined preload. Cardiomyocytes remodel the h

br Experimental Procedures br Author Contributions

2018-10-20

Experimental Procedures Author Contributions Acknowledgments We thank Toshio Kitamura for PLAT-A cells, and Gregg Duester and Daniel J. Donoghue for discussions. Yoav Altman, Joseph Russo, Edward Monosov, Frederick Lo, Maria Jose Martinez Lopez, Justin D. Blethrow, and Alexey Eroshkin kindl

Hello world!

2018-07-29