• One of our most intriguing findings

  2018-11-09

  

  One of our most intriguing findings in the present study is that decreased goblet cell differentiation and mucus production were associated with severe inflammation in response to DSS in Adam17Mx1-Cre+ mice. Complete knockout of the Adam17 gene displays multiple pathological changes in several organ

• br Methods br Results The characteristics of the children in

  2018-11-09

  

  Methods Results The characteristics of the 313 children in the study are shown in Table 1. There were nearly equal numbers of girls and boys. Over 60% (194/313) of the children were stunted. A summary heatmap of the top fifty serum metabolites by HAZ is shown in Fig. 1. Serum amino MM-102 and

• In this context it is

  2018-11-09

  

  In this context, it is interesting to note that the impact of the cellular response associated with the β-catenin co-factor BCL9/9L may be context-dependent. Indeed, in the mouse, ablation of Bcl9/9l in the intestinal epithelium abrogates the expression of genes related to epithelial–mesenchymal tra

• br Author s Contributions br Funding Sources br Acknowledgem

  2018-11-09

  

  Author\'s Contributions Funding Sources Acknowledgements Introduction First isolated in 1947 from the blood of a Rhesus monkey in the Zika forest, Uganda (Dick et al., 1952), Zika virus (ZIKV) was recently declared a global public health emergency by WHO (Heymann et al., 2016). After dec

• We have previously reported the CM chip that enables precise

  2018-11-09

  

  We have previously reported the CM chip that enables precise estimation of rare cell counts in blood including spiked-in cultured cancer green (Yatsushiro et al., 2010; Yamamura et al., 2012). Although the CM chip produced excellent results in a preclinical study, we considered that precise enumera

• The recent findings clearly demonstrate the mutagenic effect

  2018-11-09

  

  The recent findings clearly demonstrate the mutagenic effect of ribavirin on the HEV genome, which can lead to an emergence of distinct viral populations (Debing et al., 2014, 2016b; Gisa et al., 2015; Todt et al., 2016). These distinct viral populations resulted from ribavirin treatment failure may

• Very little research has focused on the off

  2018-11-09

  

  Very little research has focused on the off-grid TV market (defined here as comprising both un- and under-electrified populations) because it is currently a niche market with uncertain growth potential. Demand for DC TVs in off-grid regions is currently driven by existing distributors of solar power

• Seldon has proposed that during human development white matt

  2018-11-09

  

  Seldon has proposed that during human development, white matter grows outward and expands to the overlying cortex similar to a balloon, affecting the capacity of the cortex (Seldon, 2005). The different rates of expansion in particular myeloperoxidase regions create regional differences in cortical

• The analysis shown in Figs and suggests that the influence

  2018-11-09

  

  The analysis shown in Figs. 8 and 9 suggests that the influence of small shifts in the flexor angle may be mitigated through design. Specifically, switches designed with a larger flexor angle will show smaller variation with small changes in leg angle. Therefore, we recommend that future device desi

• While obesity maintained an intense association in the bivar

  2018-11-09

  

  While obesity maintained an intense association in the bivariate analysis (OR: 9.29), this association was lost in the multivariate analysis, where it was adjusted by neck circumference, which maintained a significant association. This is consistent with the results obtained by Preis et al. [26] in

• Recordings in PPN neurons using M NCS

  2018-11-09

  

  Recordings in PPN neurons using 1μM NCS-1 were found to increase the amplitude and frequency of ramp-induced oscillations within ~25min of diffusion into the cell. Fig. 1 is a representative example of ramp-induced membrane potential oscillations in a PPN neuron in the presence of synaptic blockers

• Obstructive sleep apnoea hypopnoea syndrome OSAHS affects

  2018-11-09

  

  Obstructive sleep apnoea hypopnoea syndrome (OSAHS) affects 2–4% of middle-aged adults [1–3]. It is associated with various adverse cardiovascular outcomes [4,5] and appears an independent factor for arterial [6] and possibly venous thrombosis [7]. However, studies focusing on mechanisms to explain

• La Tabla muestra los resultados

  2018-11-09

  

  La Tabla 1 muestra los resultados de aplicar este sencillo modelo methylphenidate hcl los dos periodos de expansión más recientes y largos de la economía mexicana: entre 1960 y 1981 y entre 2008 y 2015. Lo primero que llama la atención es la aguda disminución de la tasa promedio anual de expansión d

• Comparison of our data obtained using computational methods

  2018-11-09

  

  Comparison of our data obtained using computational methods and findings obtained using experimental approaches, based on structural and biochemical characterisation, shows remarkable consistency (Figs. 2A and 3). In particular, the computational study (Table 1 and Supplemental Tables S4 and S7) em

• The mathematical models used here are

  2018-11-09

  

  The mathematical models used here are simplistic representations of modeled epidemics and as such their projections, although comparable with the results of other modeling studies in similar populations (Gray et al., 2011; Hontelez et al., 2011; Andersson et al., 2011), shouldn\'t be perceived as co

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