• There are a number of reasons

  2018-11-05

  

  There are a number of reasons that make the possibility to use blood-based miRNA signatures as diagnostic tools very attractive: i) cancer can be diagnosed in a minimally invasive way through a simple blood test; ii) a blood test does not require hospitalization and the access to complex and expensi

• The recent Zika virus ZIKV outbreak has been declared a

  2018-11-05

  

  The recent Zika virus (ZIKV) outbreak has been declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization in February 2016. It started in Brazil in 2015, rapidly spread through South and Central America, and is expected to reach the continental US in the sum

• br Conflicts of Interest br Author

  2018-11-05

  

  Conflicts of Interest Author Contributions Introduction The physiological capacity to coordinate dynamic neural activity within and between neural networks is believed to underlie normal cognitive processes (Fenton, 2015). This Mitiglinide Calcium is largely based upon studies that have ob

• It remains controversial how SMase and or SMS is

  2018-11-05

  

  It remains controversial how SMase and/or SMS is regulated in the organs of animals fed a HFD. It has been reported that three weeks of HFD feeding induces a pronounced SM (including SM(d18:1/16:0)) accumulation in liver tissues, accompanied by decreased activity of aSMase but increased nSMase activ

• Influenza proteins inside the viral envelope are

  2018-11-05

  

  Influenza proteins inside the viral envelope are highly conserved across different strains and subtypes of influenza. Two internal proteins that have been extensively studied in the context of influenza infection are nucleoprotein (NP) and matrix protein 1 (M1). NP binds and transports the RNA genom

• matrix metalloproteinases br Introduction Various source der

  2018-11-05

  

  Introduction Various source-derived mesenchymal stem matrix metalloproteinases (MSCs) show promise as cell-based therapies. They have emerged as a productive, feasible, accepted, and universal source by various methods of MSC isolation (Karahuseyinoglu et al., 2007; Frausin et al., 2015). Previou

• Different formats have been developed for detection of resis

  2018-11-05

  

  Different formats have been developed for detection of resistance conferring mutations in MTB. Compared to the GeneXpert MTB/RIF assay (Boehme et al., 2010) which is limited to the detection of rifampicin resistance, line probe assays are particularly attractive due to their unmatched versatility, i

• Our previous studies identified dysfunctional sphingolipid m

  2018-11-05

  

  Our previous studies identified dysfunctional sphingolipid metabolism, due to pathological activation of ASM in diabetic retina and bone marrow, as an important metabolic insult contributing to pro-inflammatory changes in the retina and development of diabetic retinopathy (Opreanu et al., 2011; Tikh

• miR a and miR b are two miRNAs of the

  2018-11-05

  

  miR-146a and miR-146b are two miRNAs of the same family that share the same seed sequence and only differ by two nucleotides at the 3′ end in their mature sequences. However, they are encoded by distinct genes located on separate chromosomes, which implies that they may fulfil distinct functions. In

• br Outstanding Questions The therapeutics

  2018-11-05

  

  Outstanding Questions The therapeutics mentioned in this review are a small sample of some of the most promising clinical pharmacological approaches to tackling age-related diseases. Assessing the potential systemic anti-ageing effects of therapeutics currently used to treat specific age-related

• Despite its benefits as a powerful form of communication

  2018-11-05

  

  Despite its benefits as a powerful form of communication (see Barker & Gower, 2010; Hegarty, 2011, p. 95; Smith, 2011, p. 27), the fact is that stories remain a largely unconventional means of brand communication (Barker & Gower, 2010). In the III National Conference of Retail that took place in Ba

• In this paper solid state and sonochemical reaction methods

  2018-11-05

  

  In this paper, solid state and sonochemical reaction methods are used to produce the Mgdoped bulk and nano LSMMO (0.050 ≤ x ≤ 0.100) manganite perovskite, respectively. The structural as well as the magnetic properties of LSMMO manganite perovskites are revealed employing different characterisation

• Introduction Steel and its alloys are widely used in industr

  2018-11-05

  

  Introduction Steel and its alloys are widely used in industrial applications, and may be subjected to different acidic environments. Acids attack metal surface and lead to severe corrosion problems. Corrosion can be controlled by using inhibitors. Most of the well-known GDC-0994 inhibitors used in

• In narcolepsy cataplexy there is

  2018-11-05

  

  In narcolepsy–cataplexy, there is an increase in the incidence of REM sleep behavioral disorder (RBD) [77]. In RBD the mechanisms that produce atonia are significantly reduced, which supports the hypothesis that the dysfunction of the hypocretinergic system produces instability of motor regulatory s

• The etiology was considered idiopathic in all cases

  2018-11-05

  

  The etiology was considered idiopathic in all cases, based on the high number of complementary exams performed. In the 6 cases in whom the anti-streptolysin-O levels was obtained, only one demonstrated a mildly high level, which does not support the hypothesis of streptococcal infection as a main tr

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