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Liposomes that are less than nm in
2022-03-09
Liposomes that are less than 200nm in diameter are necessary to optimize uptake of liposomes by Mesoridazine (Oesterling et al., 2014). The liposomes constructed in these experiments were found to be sufficiently small in diameter for use in in vivo and in vitro experiments. Even smaller diameters
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br Experimental br Results and discussions
2022-03-08
Experimental Results and discussions Conclusions Declaration of interests Acknowledgements Financial support from the National Natural Science Foundation of China (21605089 and 81773483), the Ningbo Municipal Natural Science Foundation (2017A610228 and 2018A610217), the Open Subject o
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Annexin V-Cy3 Apoptosis Kit Sometime ago we have described
2022-03-08
Sometime ago we have described diamino-1,3,5-triazines as histamine H4R ligands,12, 13 and aryl derivatives of the 1,3,5-triazine, which attenuated inflammatory and nociceptive response in vivo in the rodent models of inflammation induced by Annexin V-Cy3 Apoptosis Kit and zymosan. In this work we
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In comparing the amounts of total
2022-03-08
In comparing the amounts of total GST activity of the rabbit cornea, porcine cornea and Hemicornea construct (Fig. 4A), the construct was found to exhibit an obviously lower level of GST activity. To assess these findings, it Olomoucine will be necessary to compare them to the level in the human co
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Glycogen synthase kinase GSK a serine threonine kinase
2022-03-08
Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase, has been confirmed to be involved in some biological processes in NaCl or wound-treated plants (Chen et al., 2003, Hai et al., 2001, Jonak et al., 2000). NO has been recently recognized as a vital signaling compound in plants. The NO don
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Boc-D-FMK The opposite modulation observed for circulating L
2022-03-08
The opposite modulation observed for circulating LPI levels and WAT GPR55 Boc-D-FMK by nutritional status suggests that increased levels of LPI may down-regulate the expression of its receptor in WAT, whereas in conditions of low serum LPI levels, the expression of GPR55 is stimulated. However, duri
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Neurotransmitter transporters are rapidly recycled from and
2022-03-08
Neurotransmitter transporters are rapidly recycled from and to the membrane. For instance, the GABA transporter GAT1 is recycled in a calcium and depolarization dependent manner. GAT1 located in the plasma membrane is internalized to a subpopulation of small vesicles different from the classical neu
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BCCA occlusion followed by reperfusion injury significantly
2022-03-08
BCCA occlusion, followed by reperfusion injury, significantly increased the brain AT1 and AT2 receptor expression in mice. Reports have demonstrated elevation of AT1 receptor expression in the cerebral Ion Channel Compound Library sale during ischemia [34,35]. The gene expression of brain AT2 recep
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Introduction l Glutamate is a major excitatory neurotransmit
2022-03-08
Introduction l-Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system (CNS) that contributes not only to fast synaptic neurotransmission, but also to complex physiological processes like memory, learning, plasticity, and neuronal cell death [30], [81]. Glutamate is
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br Dysregulation of glutamate transporter expression
2022-03-08
Dysregulation of glutamate transporter expression and function Aberrant glutamate transporter function and expression are associated with various neurological disorders. Therefore, understanding the underlying mechanisms of EAAT1/2 expression may provide therapeutic targets for treating neurologi
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Interestingly when glucose is deleted in
2022-03-08
Interestingly, when glucose is deleted in PCa cells, GLUT1 is increased. Also, AR is almost entirely located in the nucleus, correlating with the increment in GLUT1 levels. These results are in agreement with those reported by Vaz et al. [16], They described an increase in GLUT1 after DHT stimulatio
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Dihydroartemisinin This GluR A independent mechanism
2022-03-08
This GluR-A-independent mechanism, by which the associative strength of spatial locations can be increased (and/or decreased) gradually over many trials, and which presumably underlies spatial reference memory acquisition during tasks such as the Morris watermaze or the radial maze (Zamanillo et al.
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br Materials and methods Rat forebrains were
2022-03-08
Materials and methods Rat forebrains were obtained from Sprague–Dawley rats at 2, 7, 14, 21, and 30–35 postnatal days and were homogenized in 1:5 volumes (w/v) of 0.32 M sucrose containing 1 mM EGTA, 1 mM EDTA, 1 μg/ml TPCK, 50 μM leupeptin, and 3 μM antipain with 10 strokes in a glass-teflon hom
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We have previously shown in the same time
2022-03-08
We have previously shown in the same time frame reported here (10 min) that AG was not degraded into DAG [29] and that the half-life of AG in human serum is ∼10 min [49]. However, we cannot rule out in this study that there is not breakdown to DAG that could contribute to the levels of 125I-ghrelin
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G quadruplex DNA structures may exist in
2022-03-07
G-quadruplex DNA structures may exist in either positive or negative strand of a promoter to regulate gene expression. The positive strand of the HOXC10 promoter is overall C-rich in the 1000 bp upstream of the TSS (36.6% of C versus 24.1% of G) and contains many C-runs; thus, G-quadruplex structure
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