• Acknowledgements br Introduction The neurotransmitter glycin

  2022-02-22

  

  Acknowledgements Introduction The neurotransmitter glycine acts through two receptors: a strychnine-sensitive glycine receptor (GlyA) and a strychnine-insensitive glycine receptor (GlyB). GlyA is localized to the neuronal membrane post-synaptic to inhibitory glycinergic neurons, whereas GlyB is

• Finally the formation of a regular network of

  2022-02-22

  

  Finally, the formation of a regular network of fusion glycoproteins in their post-fusion state is not exclusive of vesiculovirus G. More or less regular networks have been also observed with other class III fusion glycoproteins such as pseudorabies gB [85] and several class II fusion glycoproteins [

• br Acknowledgement This work was supported in

  2022-02-22

  

  Acknowledgement This work was supported in part by grants from the Ministerio de Economía y Competitividad from Spain (BFU2011-23034). Introduction The glutamate hypothesis of schizophrenia emerged from observations in the 1960s that phencyclidine and similar psychotomimetic agents produce sc

• br Introduction Prostate cancer is the most commonly diagnos

  2022-02-22

  

  Introduction Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer deaths in men in the United States, accounting for about 30,000 cancer deaths annually [1]. Epidemiological studies that show geographical variations in prostate cancer incidence and mortalit

• Increased expression of Glut is

  2022-02-22

  

  Increased expression of Glut1 is detected in a number of cancer types including lung [7], brain [8], bladder [9], cervical [10], colorectal [11], esophageal [12], hepatocellular [13], head and neck [14], gastric [15], ovarian [16], renal cell [17], pancreatic [18], thyroid [19] and breast [20]. Over

• Interestingly when glucose is deleted in PCa cells

  2022-02-22

  

  Interestingly, when glucose is deleted in PCa cells, GLUT1 is increased. Also, AR is almost entirely located in the nucleus, correlating with the increment in GLUT1 levels. These results are in agreement with those reported by Vaz et al. [16], They described an increase in GLUT1 after DHT stimulatio

• Animal studies have shown that various antidepressant

  2022-02-22

  

  Animal studies have shown that various antidepressant treatment are capable of upregulating GR protein and mRNA in key Chlorambucil regions including the hippocampus and decreasing basal and/or stress-induced glucocorticoid secretion [37]. Changes in the level or function of GR regulate the negative

• br Results br Discussion Using a novel viral vector for

  2022-02-22

  

  Results Discussion Using a novel viral vector for norepinephrine-targeted gene deletion, we have shown that glucocorticoid receptor Fmoc-Phe-OH synthesis from locus coeruleus norepinephrine neurons reduces social interaction specifically in female mice. This effect is not attributable to chan

• Recently multiple receptor agonists have

  2022-02-22

  

  Recently, multiple receptor agonists have been developed to treat type II diabetes (Finan et al., 2013, Finan et al., 2015). We have tested novel dual GLP-1/GIP receptor agonists that showed good neuroprotective effects that are superior to single GLP-1 analogues (Cao et al., 2016, Jalewa et al., 20

• The molecular nature of these putative

  2022-02-22

  

  The molecular nature of these putative Ca2+ Ramiprilat synthesis is at present unknown. Apart from the NSVDC channel, which is permeable to Ca2+ [27], [15] functional Ca2+ channels have been identified in patch clamp experiments [28]. These channels, which were characterized as B-channels, seem to

• Baicalin The current gold standard for diagnosing BAM

  2022-02-21

  

  The current gold standard for diagnosing BAM or BAD is the measurement of BA turnover rate with radiolabelled tauroselcholic (75selenium) Baicalin (also known as the SeHCAT retention test). SeHCAT test involves the use of a synthetic analogue of naturally occurring conjugated taurocholic acid and m

• The PI K AKT pathway

  2022-02-21

  

  The PI3K/AKT pathway is known to affect cell cycle, survival, and apoptosis (Yu et al., 2006; Park et al., 2008). After phosphorylation by AKT, the cytoplasmic apoptotic protein bad (bcl-xl/bcl-2) cannot be transferred to the mitochondria and dissociates from the inhibition protein bcl-2 and bcl-xl,

• Since stroke and cerebrovascular diseases were considered se

  2022-02-21

  

  Since stroke and cerebrovascular diseases were considered serious AEs following vaccination, we performed manual chart review to confirm the diagnosis and symptom onset date for all stroke and cerebrovascular disease cases identified by ICD-9 codes. Chart review of 131 presumptive cases confirmed 82

• br Results br Discussion Our current study demonstrates that

  2022-02-21

  

  Results Discussion Our current study demonstrates that the sustained activation of Yap overrides the p27-mediated checkpoint, at least in part, through the degradation of FoxO family proteins, allowing polyploid cells to proliferate inappropriately with mitotic defects and resulting in centros

• The zinc dependent HDACs are

  2022-02-21

  

  The zinc-dependent HDACs are classified into four groups based on their structure, complex formation, and expression pattern: class I (HDAC1, HDAC2, HDAC3, and HDAC8), class IIa (HDAC4, HDAC5, HDAC7, and HDAC9), class IIb (HDAC6 and HDAC10), and class IV (HDAC11) [16]. We recently reported on a cyto

15918 records 469/1062 page Previous Next First page 上5页 466467468469470 下5页 Last page