• The development of immobilization techniques for

  2021-12-10

  

  The development of immobilization techniques for β-glucosidase offers a potential way to enable its reuse several times [13]. The aim of immobilization is to trap the enzyme within or on the surface of an insoluble material with retention of its catalytic activity [14]. The immobilization strategy a

• To support maximal growth and metabolic function

  2021-12-10

  

  To support maximal growth and metabolic function of major organs, glucose and Pertussis Toxin are essential. We assessed the plasma levels of glucose and amino acids in LBW and NBW piglets at birth and at day 7 postpartum. Blood glucose levels were influenced by birthweight and age. In this study,

• BMS 470539 dihydrochloride australia The identification of d

  2021-12-10

  

  The identification of distinct expression domains in the limb suggested that these domains might have specific biological functions. We explored this possibility by determining enriched biological processes for each category using GO ontology term analysis (WebGestalt) (Zhang et al., 2005). Category

• A model substance often used in

  2021-12-10

  

  A model substance often used in the studies of oxidative processes in erythrocytes is tert-butyl hydroperoxide (t-BHP), which, being lipophilic, passes easily across the erythrocyte membrane [9]. In erythrocytes treated with t-BHP (0.1–3mM) for less than 1h, a dramatic decline in the reduced glutath

• Thus this work aims to evaluate the effect

  2021-12-10

  

  Thus, this work aims to evaluate the effect of tannic Cy3-dUTP on β-galactosidase activity, by observing the variations in the molecular interaction kinetic parameters ( and ). Besides, these data were correlated with the modifications that the tannin caused to the enzyme’s secondary structure (CD),

• The structural similarity software vROCS

  2021-12-10

  

  The structural similarity software vROCS (OpenEye) [45] has been utilized by Musumeci et al. [46] to screen the Maybridge [47] HitFinder database (∼14,400 compounds) using Distamycin A (Fig. 3B) as a query. Using the Tanimoto coefficient (Section 6.4) and vROCS's colour scoring (atom/feature similar

• Preliminary explorations focused on the linker of

  2021-12-10

  

  Preliminary explorations focused on the linker of 2 (Table 1). Lilly reported that the methylene between the phenyl and the piperidyl group was metabolically susceptible to N-dealkylation, so we replaced the methylene with a carbonyl moiety to block the metabolic site [23,48] (Fig. 2). In addition,

• br Author contributions br Acknowledgements The

  2021-12-10

  

  Author contributions Acknowledgements The work was supported in part by Natural Science Foundation of China (31601995, 31501028) and an internal research grant of Jianghan University (14042). The authors thank HY of Jingchu University of technology for revising the manuscript. Introduction

• We tested this hypothesis with two experiments In the first

  2021-12-09

  

  We tested this hypothesis with two experiments. In the first experiment OVX monkeys implanted with an E2 enkephalin (this results in LH levels similar to the level during the follicular phase) were treated with daily injections of letrozole for 1 week and then EB was injected systemically mimicking

• The aim of this study is to explore new

  2021-12-09

  

  The aim of this study is to explore new Glo-I inhibitors using the structure-based pharmacophore approach. Eighteen Glo-I co-crystallized structures have been explored to investigate their pharmacophoric features. Ninety two pharmacophoric models were generated. QSAR analysis followed by Ligand Prof

• Carbetocin The need for an inflammatory risk

  2021-12-09

  

  The need for an ‘inflammatory risk profile’ was recently discussed by several investigators. The present study is all the more significant in that it shows that a phenomenon that is influenced by various atherosclerotic risk factors and acute phase proteins is, indeed, associated with a less favorab

• br Regulation of Glu transporters The pivotal

  2021-12-09

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino nisin synthesis calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include tran

• EAATs can transport glutamate aspartate cysteic

  2021-12-09

  

  EAATs can transport glutamate, aspartate, cysteic acid, and serine-o-sulfate (Bjorn-Yoshimoto and Underhill, 2016). All EAATs work as symporters co-transporting 2 or 3 molecules of Na+ and a proton with each molecule of glutamate (or aspartate). In addition, a K+ ion is counter-transported ending in

• MicroRNA or miRNA is group of RNA molecule of about

  2021-12-09

  

  MicroRNA, or miRNA, is group of RNA molecule of about 22 nucleotides without protein-coding function. MicroRNAs are widely distributed in plants, animals and even some viruses and participant in both normal physiological and pathological processes by post-transcriptional regulation of gene expressio

• Although the ramifications of non additive SAR are context

  2021-12-09

  

  Although the ramifications of non-additive SAR are context-dependent, the knowledge that perturbations in one region of a chemical series are not synergistic with perturbations in another region of the same chemical series is clearly pertinent to any medicinal chemistry effort. In our experience, no

16003 records 519/1067 page Previous Next First page 上5页 516517518519520 下5页 Last page